An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations

PURPOSE: Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are primarily effective against BRCA1/2-mutated breast and ovarian cancers but resistance due to reversion of mutated BRCA1/2 and other mechanisms is common. Based on previous reports demonstrating a functional role for DNMT1 in DNA rep...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Pulliam, Nicholas, Fang, Fang, Ozes, Ali R., Tang, Jessica, Adewuyi, Adeoluwa, Keer, Harold, Lyons, John, Baylin, Stephen B., Matei, Daniela, Nakshatri, Harikrishna, Rassool, Feyruz V., Miller, Kathy D., Nephew, Kenneth P.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003715/
https://ncbi.nlm.nih.gov/pubmed/29615458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0204
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