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CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy

Sequence and copy number variations in the human CFHR–Factor H gene cluster comprising the complement genes CFHR1, CFHR2, CFHR3, CFHR4, CFHR5, and Factor H are linked to the human kidney diseases atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy. Distinct genetic and chromosomal altera...

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Pubblicato in:J Am Soc Nephrol
Autori principali: Zipfel, Peter F., Wiech, Thorsten, Stea, Emma D., Skerka, Christine
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003313/
https://ncbi.nlm.nih.gov/pubmed/31980588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019050515
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