Whole-Genome Sequencing of Finnish Type 1 Diabetic Siblings Discordant for Kidney Disease Reveals DNA Variants associated with Diabetic Nephropathy

BACKGROUND: Several genetic susceptibility loci associated with diabetic nephropathy have been documented, but no causative variants implying novel pathogenetic mechanisms have been elucidated. METHODS: We carried out whole-genome sequencing of a discovery cohort of Finnish siblings with type 1 diab...

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Publicado en:J Am Soc Nephrol
Autores principales: Guo, Jing, Rackham, Owen J. L., Sandholm, Niina, He, Bing, Österholm, Anne-May, Valo, Erkka, Harjutsalo, Valma, Forsblom, Carol, Toppila, Iiro, Parkkonen, Maija, Li, Qibin, Zhu, Wenjuan, Harmston, Nathan, Chothani, Sonia, Öhman, Miina K., Eng, Eudora, Sun, Yang, Petretto, Enrico, Groop, Per-Henrik, Tryggvason, Karl
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2020
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003303/
https://ncbi.nlm.nih.gov/pubmed/31919106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2019030289
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