A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna

Global gene delivery to the CNS has therapeutic importance for the treatment of neurological disorders that affect the entire CNS. Due to direct contact with the CNS, cerebrospinal fluid (CSF) is an attractive route for CNS gene delivery. A safe and effective route to achieve global gene distributio...

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Détails bibliographiques
Publié dans:Mol Ther
Auteurs principaux: Taghian, Toloo, Marosfoi, Miklos G., Puri, Ajit S., Cataltepe, Oguz.I., King, Robert M., Diffie, Elise B., Maguire, Anne S., Martin, Douglas R., Fernau, Deborah, Batista, Ana Rita, Kuchel, Tim, Christou, Chris, Perumal, Raj, Chandra, Sundeep, Gamlin, Paul D., Bertrand, Stephanie G., Flotte, Terence R., McKenna-Yasek, Diane, Tai, Phillip W.L., Aronin, Neil, Gounis, Matthew J., Sena-Esteves, Miguel, Gray-Edwards, Heather L.
Format: Artigo
Langue:Inglês
Publié: American Society of Gene & Cell Therapy 2020
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002897/
https://ncbi.nlm.nih.gov/pubmed/31813800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.012
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