A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna

Global gene delivery to the CNS has therapeutic importance for the treatment of neurological disorders that affect the entire CNS. Due to direct contact with the CNS, cerebrospinal fluid (CSF) is an attractive route for CNS gene delivery. A safe and effective route to achieve global gene distributio...

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Pubblicato in:Mol Ther
Autori principali: Taghian, Toloo, Marosfoi, Miklos G., Puri, Ajit S., Cataltepe, Oguz.I., King, Robert M., Diffie, Elise B., Maguire, Anne S., Martin, Douglas R., Fernau, Deborah, Batista, Ana Rita, Kuchel, Tim, Christou, Chris, Perumal, Raj, Chandra, Sundeep, Gamlin, Paul D., Bertrand, Stephanie G., Flotte, Terence R., McKenna-Yasek, Diane, Tai, Phillip W.L., Aronin, Neil, Gounis, Matthew J., Sena-Esteves, Miguel, Gray-Edwards, Heather L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002897/
https://ncbi.nlm.nih.gov/pubmed/31813800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.012
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