A Safe and Reliable Technique for CNS Delivery of AAV Vectors in the Cisterna Magna

Global gene delivery to the CNS has therapeutic importance for the treatment of neurological disorders that affect the entire CNS. Due to direct contact with the CNS, cerebrospinal fluid (CSF) is an attractive route for CNS gene delivery. A safe and effective route to achieve global gene distributio...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Taghian, Toloo, Marosfoi, Miklos G., Puri, Ajit S., Cataltepe, Oguz.I., King, Robert M., Diffie, Elise B., Maguire, Anne S., Martin, Douglas R., Fernau, Deborah, Batista, Ana Rita, Kuchel, Tim, Christou, Chris, Perumal, Raj, Chandra, Sundeep, Gamlin, Paul D., Bertrand, Stephanie G., Flotte, Terence R., McKenna-Yasek, Diane, Tai, Phillip W.L., Aronin, Neil, Gounis, Matthew J., Sena-Esteves, Miguel, Gray-Edwards, Heather L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002897/
https://ncbi.nlm.nih.gov/pubmed/31813800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.012
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