6-Ketocholestanol suppresses lipid accumulation by decreasing FASN gene expression through SREBP-dependent regulation in HepG2 cells

Nuclear receptors, such as liver X receptors (LXRs) and sterol regulatory element-binding proteins (SREBPs), are key regulators of lipogenic genes, including fatty acid synthase (FASN). It has been reported that several oxycholesterols (OCs) act as LXR ligands; however, it is unclear whether all OC...

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Bibliografiske detaljer
Udgivet i:Cytotechnology
Main Authors: Shirouchi, Bungo, Yanagi, Shuhei, Okawa, Chinami, Koga, Maiko, Sato, Masao
Format: Artigo
Sprog:Inglês
Udgivet: Springer Netherlands 2020
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002641/
https://ncbi.nlm.nih.gov/pubmed/31933103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-019-00368-5
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