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Glucose‐induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs

Diabetic complications cause significant morbidity and mortality. Dysfunction of vascular endothelial cells (ECs), caused by oxidative stress, is a main mechanism of cellular damage. Oxidative stress accelerates EC senescence and DNA damage. In this study, we examined the role of mitochondrial sirtu...

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Библиографические подробности
Опубликовано в: :Physiol Rep
Главные авторы: Liu, Jieting, Chen, Shali, Biswas, Saumik, Nagrani, Niharika, Chu, Yanhui, Chakrabarti, Subrata, Feng, Biao
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002531/
https://ncbi.nlm.nih.gov/pubmed/32026628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14331
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