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miR-29a is repressed by MYC in pancreatic cancer and its restoration drives tumor suppressive effects via downregulation of LOXL2
Pancreatic ductal adenocarcinoma (PDAC) is an intractable cancer with a dismal prognosis. MicroRNA-29a (miR-29a) is commonly downregulated in PDAC, however, mechanisms for its loss and role still remain unclear. Here we show that in PDAC, repression of miR-29a is directly mediated by MYC via promote...
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| Publicado no: | Mol Cancer Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7002266/ https://ncbi.nlm.nih.gov/pubmed/31662451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0594 |
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