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miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-α activation
Treatment with l-mimosine, which activates hypoxia-inducible factor-α (HIF-α), attenuates renal tubulointerstitial injury and improves renal function in a rat remnant kidney model. The miR-29 family of microRNAs directly targets a large number of extracellular matrix genes and reduces renal intersti...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651624/ https://ncbi.nlm.nih.gov/pubmed/23467423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00287.2012 |
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