Intratumoral plasmid IL-12 electroporation therapy in advanced melanoma patients induces systemic and intratumoral T cell responses: T cell responses induced by plasmid IL-12 electroporation

Whereas systemic IL-12 is associated with potentially life-threatening toxicity, intra-tumoral delivery of IL-12 through tavokinogene telseplasmid electroporation (tavo) is safe and can induce tumor regression at distant sites. The mechanism by which these responses are mediated is unknown, but is p...

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Udgivet i:Cancer Immunol Res
Main Authors: Greaney, Samantha K., Algazi, Alain P., Tsai, Katy K., Takamura, Kathryn T., Chen, Lawrence, Twitty, Christopher G., Zhang, Li, Paciorek, Alan, Pierce, Robert H., Le, Mai H., Daud, Adil I., Fong, Lawrence
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7002232/
https://ncbi.nlm.nih.gov/pubmed/31852717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0359
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