Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation

Myofibroblasts are key contributors to pathological fibrotic conditions of several major organs. Fibroblast transdifferentiation into myofibroblasts requires both a mechanical signal and transforming growth factor beta (TGF-β) signaling. The cation channel transient receptor potential vanilloid 4 (T...

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Bibliographic Details
Published in:Sci Signal
Main Authors: Grove, Lisa M., Mohan, Maradumane L., Abraham, Susamma, Scheraga, Rachel G., Southern, Brian D., Crish, James F., Prasad, Sathyamangla V. Naga, Olman, Mitchell A.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001959/
https://ncbi.nlm.nih.gov/pubmed/31719171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau1533
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