DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling

The dedicator of cytokinesis 5 (DOCK5) is associated with obesity. However, the mechanism by which DOCK5 contributes to obesity remains completely unknown. Here, we show that hepatic DOCK5 expression significantly decreases at a state of insulin resistance (IR). Deletion of DOCK5 in mice reduces ene...

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Detalhes bibliográficos
Publicado no:EMBO Rep
Main Authors: Lai, Yerui, Zhao, Anjiang, Tan, Minghong, Yang, Mengliu, Lin, Yao, Li, Shengbing, Song, Jinlin, Zheng, Hongting, Zhu, Zhiming, Liu, Dongfang, Liu, Chaohong, Li, Ling, Yang, Gangyi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001503/
https://ncbi.nlm.nih.gov/pubmed/31885214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949473
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