Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

BACKGROUND: Spinal cord injury (SCI) can lead to severe motor and sensory dysfunction with high disability and mortality. In recent years, mesenchymal stem cell (MSC)-secreted nano-sized exosomes have shown great potential for promoting functional behavioral recovery following SCI. However, MSCs are...

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Dettagli Bibliografici
Pubblicato in:J Neuroinflammation
Autori principali: Liu, Wei, Rong, Yuluo, Wang, Jiaxing, Zhou, Zheng, Ge, Xuhui, Ji, Chengyue, Jiang, Dongdong, Gong, Fangyi, Li, Linwei, Chen, Jian, Zhao, Shujie, Kong, Fanqi, Gu, Changjiang, Fan, Jin, Cai, Weihua
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001326/
https://ncbi.nlm.nih.gov/pubmed/32019561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-1726-7
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