Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis

BACKGROUND: Multiple sclerosis (MS) is a chronic debilitating immune-mediated disease of the central nervous system (CNS) driven by demyelination and gray matter neurodegeneration. We previously reported an experimental autoimmune encephalomyelitis (EAE) MS mouse model with elevated serum CXCL1 that...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Khaw, Yee Ming, Cunningham, Claire, Tierney, Abigail, Sivaguru, Mayandi, Inoue, Makoto
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001284/
https://ncbi.nlm.nih.gov/pubmed/32019585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-1730-y
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