Exosome-mediated lncRNA AFAP1-AS1 promotes trastuzumab resistance through binding with AUF1 and activating ERBB2 translation

BACKGROUND: Although trastuzumab provides significant clinical benefit for HER2-positive breast cancers, responses are limited by the emergence of resistance. Recent evidence suggests that long noncoding RNAs (lncRNAs) play important roles in tumorigenesis and chemoresistance. However, the regulator...

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Vydáno v:Mol Cancer
Hlavní autoři: Han, Mingli, Gu, Yuanting, Lu, Pengwei, Li, Jingyi, Cao, Hui, Li, Xiangke, Qian, Xueke, Yu, Chao, Yang, Yunqing, Yang, Xue, Han, Na, Dou, Dongwei, Hu, Jianguo, Dong, Huaying
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001272/
https://ncbi.nlm.nih.gov/pubmed/32020881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-020-1145-5
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