Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer

BACKGROUND: Trastuzumab resistance followed by metastasis is a major obstacle for improving the clinical outcome of patients with advanced human epidermal growth factor receptor 2-positive (HER-2+) breast cancer. While long non-coding RNAs (lncRNAs) can modulate cell behavior, the contribution of th...

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書目詳細資料
發表在:Mol Cancer
Main Authors: Dong, Huaying, Hu, Jianguo, Zou, Kejian, Ye, Mulin, Chen, Yuanwen, Wu, Chengyi, Chen, Xin, Han, Mingli
格式: Artigo
語言:Inglês
出版: BioMed Central 2019
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323810/
https://ncbi.nlm.nih.gov/pubmed/30621694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-018-0931-9
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