Coactivation of Endogenous Wnt10b and Foxc2 by CRISPR Activation Enhances BMSC Osteogenesis and Promotes Calvarial Bone Regeneration

CRISPR activation (CRISPRa) is a burgeoning technology for programmable gene activation, but its potential for tissue regeneration has yet to be fully explored. Bone marrow-derived mesenchymal stem cells (BMSCs) can differentiate into osteogenic or adipogenic pathways, which are governed by the Wnt...

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Bibliografiska uppgifter
I publikationen:Mol Ther
Huvudupphovsmän: Hsu, Mu-Nung, Huang, Kai-Lun, Yu, Fu-Jen, Lai, Po-Liang, Truong, Anh Vu, Lin, Mei-Wei, Nguyen, Nuong Thi Kieu, Shen, Chih-Che, Hwang, Shiaw-Min, Chang, Yu-Han, Hu, Yu-Chen
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Gene & Cell Therapy 2020
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001053/
https://ncbi.nlm.nih.gov/pubmed/31882321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.029
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