GPR108 Is a Highly Conserved AAV Entry Factor

Adeno-associated virus (AAV) is a highly promising gene transfer vector, yet major cellular requirements for AAV entry are poorly understood. Using a genome-wide CRISPR screen for entry of evolutionarily divergent serotype AAVrh32.33, we identified GPR108, a member of the G protein-coupled receptor...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther
Auteurs principaux: Dudek, Amanda M., Zabaleta, Nerea, Zinn, Eric, Pillay, Sirika, Zengel, James, Porter, Caryn, Franceschini, Jennifer Santos, Estelien, Reynette, Carette, Jan E., Zhou, Guo Ling, Vandenberghe, Luk H.
Format: Artigo
Langue:Inglês
Publié: American Society of Gene & Cell Therapy 2020
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000996/
https://ncbi.nlm.nih.gov/pubmed/31784416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.005
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