The microenvironmental and metabolic aspects of sorafenib resistance in hepatocellular carcinoma

In most cases, sorafenib-resistant HCC cells exhibit significant mesenchymal phenotype and stemness features. In this context, tumor cells might undergo cell fate transition in response to sorafenib or other targeted drugs in the presence or absence of genetic mutations. Therefore, understanding the...

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Udgivet i:EBioMedicine
Main Authors: Xia, Shunjie, Pan, Yu, Liang, Yuelong, Xu, Junjie, Cai, Xiujun
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000339/
https://ncbi.nlm.nih.gov/pubmed/31918403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.102610
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