A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients

PURPOSE: Despite the rapid uptake of multigene panel testing (MGPT) for hereditary cancer predisposition, there is limited guidance surrounding indications for testing and genes to include. METHODS: To inform the clinical approach to hereditary cancer MGPT, we comprehensively evaluated 32 cancer pre...

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Bibliographic Details
Published in:Genet Med
Main Authors: LaDuca, Holly, Polley, Eric C., Yussuf, Amal, Hoang, Lily, Gutierrez, Stephanie, Hart, Steven N., Yadav, Siddhartha, Hu, Chunling, Na, Jie, Goldgar, David E., Fulk, Kelly, Smith, Laura Panos, Horton, Carolyn, Profato, Jessica, Pesaran, Tina, Gau, Chia-Ling, Pronold, Melissa, Davis, Brigette Tippin, Chao, Elizabeth C., Couch, Fergus J., Dolinsky, Jill S.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group US 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000322/
https://ncbi.nlm.nih.gov/pubmed/31406321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-019-0633-8
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