A clinical guide to hereditary cancer panel testing: evaluation of gene-specific cancer associations and sensitivity of genetic testing criteria in a cohort of 165,000 high-risk patients

PURPOSE: Despite the rapid uptake of multigene panel testing (MGPT) for hereditary cancer predisposition, there is limited guidance surrounding indications for testing and genes to include. METHODS: To inform the clinical approach to hereditary cancer MGPT, we comprehensively evaluated 32 cancer pre...

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Bibliografski detalji
Izdano u:Genet Med
Glavni autori: LaDuca, Holly, Polley, Eric C., Yussuf, Amal, Hoang, Lily, Gutierrez, Stephanie, Hart, Steven N., Yadav, Siddhartha, Hu, Chunling, Na, Jie, Goldgar, David E., Fulk, Kelly, Smith, Laura Panos, Horton, Carolyn, Profato, Jessica, Pesaran, Tina, Gau, Chia-Ling, Pronold, Melissa, Davis, Brigette Tippin, Chao, Elizabeth C., Couch, Fergus J., Dolinsky, Jill S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group US 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000322/
https://ncbi.nlm.nih.gov/pubmed/31406321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-019-0633-8
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