Ontological analyses reveal clinically-significant clear cell renal cell carcinoma subtypes with convergent evolutionary trajectories into an aggressive type

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is a particularly challenging tumor type because of its extensive phenotypic variability as well as intra-tumoral heterogeneity (ITH). Clinically, this complexity has been reduced to a handful of pathological variables such as stage, grade and necr...

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Foilsithe in:EBioMedicine
Main Authors: Cai, Qi, Christie, Alana, Rajaram, Satwik, Zhou, Qinbo, Araj, Ellen, Chintalapati, Suneetha, Cadeddu, Jeffrey, Margulis, Vitaly, Pedrosa, Ivan, Rakheja, Dinesh, McKay, Renee M., Brugarolas, James, Kapur, Payal
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2019
Ábhair:
Research paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7000318/
https://ncbi.nlm.nih.gov/pubmed/31859241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.10.052
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