Jmjd1c is dispensable for healthy adult hematopoiesis and Jak2(V617F)-driven myeloproliferative disease initiation in mice

The histone demethylase JMJD1C is overexpressed in patients with myeloproliferative neoplasms (MPNs) and has been implicated in leukemic stem cell function of MLL-AF9 and HOXA9-driven leukemia. In the emerging field of histone demethylase inhibitors, JMJD1C therefore became a potential target. Deple...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Staehle, Hans F., Heinemann, Johannes, Gruender, Albert, Omlor, Anne M., Pahl, Heike Luise, Jutzi, Jonas Samuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6999878/
https://ncbi.nlm.nih.gov/pubmed/32017785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0228362
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