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Specific N‐demethylation of verapamil by cytochrome P450 from Streptomyces griseus ATCC 13273
Norverapamil, the N‐demethylated derivative of verapamil, is a novel promising leading compound for attenuating multidrug resistance with less side effects compared with verapamil. However, the efficient synthetic method for norverapamil is absent. In this study, an innovative biotechnological metho...
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| Publicat a: | Eng Life Sci |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6999465/ https://ncbi.nlm.nih.gov/pubmed/32625009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/elsc.201800116 |
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