Producing defucosylated antibodies with enhanced in vitro antibody‐dependent cellular cytotoxicity via FUT8 knockout CHO‐S cells

To engineer a host cell line that produces defucosylated mAbs with superior antibody‐dependent cellular cytotoxicity, we disrupted α‐1, 6 fucosyltransferase (FUT8) gene in CHO‐S (CHO is Chinese hamster ovary) cells by clustered regularly interspaced short palindromic repeats‐CRISPR associated nuclea...

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Bibliographische Detailangaben
Veröffentlicht in:Eng Life Sci
Hauptverfasser: Zong, Huifang, Han, Lei, Ding, Kai, Wang, Jiaxian, Sun, Tao, Zhang, Xinyu, Cagliero, Cedric, Jiang, Hua, Xie, Yueqing, Xu, Jianrong, Zhang, Baohong, Zhu, Jianwei
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6999357/
https://ncbi.nlm.nih.gov/pubmed/32624826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/elsc.201600255
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