The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells

GPR4 is a pH-sensing G protein-coupled receptor highly expressed in vascular endothelial cells and can be activated by protons in the inflamed tissue microenvironment. Herein, we report that acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelia...

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Publicado en:iScience
Main Authors: Krewson, Elizabeth A., Sanderlin, Edward J., Marie, Mona A., Akhtar, Shayan Nik, Velcicky, Juraj, Loetscher, Pius, Yang, Li V.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997876/
https://ncbi.nlm.nih.gov/pubmed/32058960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.100848
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