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HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway

Long-term and high dose glucocorticoid treatment can cause decreased viability and function of osteoblasts, which leads to osteoporosis and osteonecrosis. In this study, we investigated the role and mechanism of action of HIF-1α in glucocorticoid-induced osteogenic inhibition in MC3T3-E1 cells. Our...

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Bibliografiske detaljer
Udgivet i:Front Endocrinol (Lausanne)
Main Authors: Xu, Wen-Ning, Zheng, Huo-Liang, Yang, Run-Ze, Jiang, Lei-Sheng, Jiang, Sheng-Dan
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997475/
https://ncbi.nlm.nih.gov/pubmed/32047474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2019.00922
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