Beta-Glycerophosphate-Induced ORAI1 Expression and Store Operated Ca(2+) Entry in Megakaryocytes

Impairment of renal phosphate elimination in chronic kidney disease (CKD) leads to enhanced plasma and tissue phosphate concentration, which in turn up-regulates transcription factor NFAT5 and serum & glucocorticoid-inducible kinase SGK1. The kinase upregulates ORAI1, a Ca(2+)-channel accomplish...

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Publicat a:Sci Rep
Autors principals: Pelzl, Lisann, Sahu, Itishri, Ma, Ke, Heinzmann, David, Bhuyan, Abdulla Al Mamun, al-Maghout, Tamer, Sukkar, Basma, Sharma, Yamini, Marini, Irene, Rigoni, Flaviana, Artunc, Ferruh, Cao, Hang, Gutti, Ravi, Voelkl, Jakob, Pieske, Burkert, Gawaz, Meinrad, Bakchoul, Tamam, Lang, Florian
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6997179/
https://ncbi.nlm.nih.gov/pubmed/32015442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58384-x
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