ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP

Angiotensin-converting enzyme (ACE) affects blood pressure. In addition, ACE overexpression in myeloid cells increases their immune function. Using MS and chemical analysis, we identified marked changes of intermediate metabolites in ACE-overexpressing macrophages and neutrophils, with increased cel...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Cao, Duo-Yao, Spivia, Weston R., Veiras, Luciana C., Khan, Zakir, Peng, Zhenzi, Jones, Anthony E., Bernstein, Ellen A., Saito, Suguru, Okwan-Duodu, Derick, Parker, Sarah J., Giani, Jorge F., Divakaruni, Ajit S., Van Eyk, Jennifer E., Bernstein, Kenneth E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996878/
https://ncbi.nlm.nih.gov/pubmed/31871049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011244
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