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Pd-Catalyzed Alkene Difunctionalization Reactions of Malonate Nucleophiles. Synthesis of Substituted Cyclopentanes via Alkene Aryl-Alkylation and Akenyl-Alkylation.

The Pd-catalyzed coupling of malonate nucleophiles with alkenes bearing tethered aryl or alkenyl triflates is described. These alkene difunctionalization reactions afford malonate-substituted cyclopentanes that contain fused aryl or cycloalkenyl rings. The transformations generate a five-membered ri...

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Foilsithe in:Org Lett
Main Authors: White, Derick R., Hinds, Elsa M., Bornowski, Evan C., Wolfe, John P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996780/
https://ncbi.nlm.nih.gov/pubmed/31021646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b01258
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