Histone H2A phosphorylation recruits topoisomerase IIα to centromeres to safeguard genomic stability

Chromosome segregation in mitosis requires the removal of catenation between sister chromatids. Timely decatenation of sister DNAs at mitotic centromeres by topoisomerase IIα (TOP2A) is crucial to maintain genomic stability. The chromatin factors that recruit TOP2A to centromeres during mitosis rema...

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Publicado en:EMBO J
Autores principales: Zhang, Miao, Liang, Cai, Chen, Qinfu, Yan, Haiyan, Xu, Junfen, Zhao, Hongxia, Yuan, Xueying, Liu, Jingbo, Lin, Shixian, Lu, Weiguo, Wang, Fangwei
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996575/
https://ncbi.nlm.nih.gov/pubmed/31769059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019101863
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