NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

The intestinal stem cell (ISC) marker LGR5 is a receptor for R‐spondin (RSPO) that functions to potentiate Wnt signalling in the proliferating crypt. It has been recently shown that Wnt plays a priming role for ISC self‐renewal by inducing RSPO receptor LGR5 expression. Despite its pivotal role in h...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Novellasdemunt, Laura, Kucharska, Anna, Jamieson, Cara, Prange‐Barczynska, Maria, Baulies, Anna, Antas, Pedro, van der Vaart, Jelte, Gehart, Helmuth, Maurice, Madelon M, Li, Vivian SW
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996568/
https://ncbi.nlm.nih.gov/pubmed/31867777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019102771
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