USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination

The tumor suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancers (CRCs), resulting in constitutive Wnt activation. To understand the Wnt-activating mechanism of the APC mutation, we applied CRISPR/Cas9 technology to engineer various APC-truncated isogenic lines. We fi...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Novellasdemunt, Laura, Foglizzo, Valentina, Cuadrado, Laura, Antas, Pedro, Kucharska, Anna, Encheva, Vesela, Snijders, Ambrosius P., Li, Vivian S.W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5656747/
https://ncbi.nlm.nih.gov/pubmed/29045831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.072
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