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GBT440 IMPROVES RED BLOOD CELL DEFORMABILITY AND REDUCES VISCOSITY OF SICKLE CELL BLOOD UNDER DEOXYGENATED CONDITIONS
BACKGROUND: In sickle cell disease (SCD), polymerization of hemoglobin S (HbS) leads to the formation of rigid, non-deformable sickled RBCs. Loss of RBC deformability, sickling and irreversible membrane damage causes abnormal blood rheology, and increases viscosity which contributes to vasoocclusion...
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| izdano v: | Clin Hemorheol Microcirc |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6996409/ https://ncbi.nlm.nih.gov/pubmed/29660913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/CH-170340 |
| Oznake: |
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