Changes in the R‐region interactions depend on phosphorylation and contribute to PKA and PKC regulation of the cystic fibrosis transmembrane conductance regulator chloride channel

The CFTR chloride channel is regulated by phosphorylation at PKA and PKC consensus sites within its regulatory region (R‐region) through a mechanism, which is still not completely understood. We used a split‐CFTR construct expressing the N‐term‐TMD1‐NBD1 (Front Half; FH), TMD2‐NBD2‐C‐Term (Back Half...

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Vydáno v:FASEB Bioadv
Hlavní autoři: Poroca, Diogo R., Amer, Noha, Li, Audrey, Hanrahan, John W., Chappe, Valerie M.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996395/
https://ncbi.nlm.nih.gov/pubmed/32123855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2019-00053
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