Changes in the R‐region interactions depend on phosphorylation and contribute to PKA and PKC regulation of the cystic fibrosis transmembrane conductance regulator chloride channel

The CFTR chloride channel is regulated by phosphorylation at PKA and PKC consensus sites within its regulatory region (R‐region) through a mechanism, which is still not completely understood. We used a split‐CFTR construct expressing the N‐term‐TMD1‐NBD1 (Front Half; FH), TMD2‐NBD2‐C‐Term (Back Half...

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Bibliografiska uppgifter
I publikationen:FASEB Bioadv
Huvudupphovsmän: Poroca, Diogo R., Amer, Noha, Li, Audrey, Hanrahan, John W., Chappe, Valerie M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996395/
https://ncbi.nlm.nih.gov/pubmed/32123855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2019-00053
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