Changes in the R‐region interactions depend on phosphorylation and contribute to PKA and PKC regulation of the cystic fibrosis transmembrane conductance regulator chloride channel

The CFTR chloride channel is regulated by phosphorylation at PKA and PKC consensus sites within its regulatory region (R‐region) through a mechanism, which is still not completely understood. We used a split‐CFTR construct expressing the N‐term‐TMD1‐NBD1 (Front Half; FH), TMD2‐NBD2‐C‐Term (Back Half...

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Bibliografische gegevens
Gepubliceerd in:FASEB Bioadv
Hoofdauteurs: Poroca, Diogo R., Amer, Noha, Li, Audrey, Hanrahan, John W., Chappe, Valerie M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6996395/
https://ncbi.nlm.nih.gov/pubmed/32123855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2019-00053
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