Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1α induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis

BACKGROUND: Diabetic patients are highly vulnerable to hypoxic injury, which is associated with hypoxia induced BNIP3 expression that subsequently activate apoptosis. Our previous research show that Tetramethylpyrazine (TMP), a food flavoring agent, represses the hypoxia induced BNIP3 expression att...

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Bibliografiske detaljer
Udgivet i:Nutr Metab (Lond)
Main Authors: Liu, Shih-Ping, Shibu, Marthandam Asokan, Tsai, Fuu-Jen, Hsu, Yuan-Man, Tsai, Chang-Hai, Chung, Jing-Gung, Yang, Jai-Sing, Tang, Chih-Hsin, Wang, Shulin, Li, Qiaowen, Huang, Chih-Yang
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995207/
https://ncbi.nlm.nih.gov/pubmed/32021640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12986-020-0432-x
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