Targeting the NAD(+) salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level

BACKGROUND: The role and mechanism of the nicotinamide adenine dinucleotide (NAD(+)) salvage pathway in cancer cell proliferation is poorly understood. Nicotinamide phosphoribosyltransferase (NAMPT), which converts nicotinamide into NAD(+), is the rate-limiting enzyme in the NAD(+) salvage pathway....

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Bibliografiske detaljer
Udgivet i:Cell Commun Signal
Main Authors: Ye, Chenyang, Qi, Lina, Li, Xiaofen, Wang, Ji, Yu, Jiekai, Zhou, Biting, Guo, Cheng, Chen, Jiani, Zheng, Shu
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995173/
https://ncbi.nlm.nih.gov/pubmed/32005247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-0513-5
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