G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense

BACKGROUND: G-protein-coupled estrogen receptor (GPER/GPR30) is a novel membrane-associated estrogen receptor that can induce rapid kinase signaling in various cells. Activation of GPER can prevent hippocampal neuronal cell death following transient global cerebral ischemia (GCI), although the mecha...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Bai, Ning, Zhang, Quanguang, Zhang, Wenli, Liu, Bin, Yang, Fang, Brann, Darrell, Wang, Ruimin
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995076/
https://ncbi.nlm.nih.gov/pubmed/32007102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-1715-x
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