Extrinsic Primary Afferent Neurons Link Visceral Pain to Colon Motility Through a Spinal Reflex in Mice

BACKGROUND & AIMS: Proper colon function requires signals from extrinsic primary afferent neurons (ExPANs) located in spinal ganglia. Most ExPANs express the vanilloid receptor TRPV1, and a dense plexus of TRPV1-positive fibers is found around myenteric neurons. Capsaicin, a TRPV1 agonist, can i...

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Publicado en:Gastroenterology
Main Authors: Smith-Edwards, Kristen M., Najjar, Sarah A., Edwards, Brian S., Howard, Marthe J., Albers, Kathryn M., Davis, Brian M.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995031/
https://ncbi.nlm.nih.gov/pubmed/31075226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.04.034
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