Metabolic dysregulation in the Atp7b(−/−) Wilson’s disease mouse model

Inactivating mutations in the copper transporter Atp7b result in Wilson’s disease. The Atp7b(−/−) mouse develops hallmarks of Wilson’s disease. The activity of several nuclear receptors decreased in Atp7b(−/−) mice, and nuclear receptors are critical for maintaining metabolic homeostasis. Therefore,...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wooton-Kee, Clavia Ruth, Robertson, Matthew, Zhou, Ying, Dong, Bingning, Sun, Zhen, Kim, Kang Ho, Liu, Hailan, Xu, Yong, Putluri, Nagireddy, Saha, Pradip, Coarfa, Cristian, Moore, David D., Nuotio-Antar, Alli M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994990/
https://ncbi.nlm.nih.gov/pubmed/31924743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914267117
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