Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testes

STUDY QUESTION: Does experimental manipulation of fibroblast growth factor 9 (FGF9)-signalling in human fetal gonads alter sex-specific gonadal differentiation? SUMMARY ANSWER: Inhibition of FGFR signalling following SU5402 treatment impaired germ cell survival in both sexes and severely altered the...

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Publicat a:Hum Reprod
Autors principals: Harpelunde Poulsen, K, Nielsen, J E, Frederiksen, H, Melau, C, Juul Hare, K, Langhoff Thuesen, L, Perlman, S, Lundvall, L, Mitchell, R T, Juul, A, Rajpert-De Meyts, E, Jørgensen, A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994936/
https://ncbi.nlm.nih.gov/pubmed/31734698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/dez191
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