Fibroblast mitochondria in idiopathic Parkinson’s disease display morphological changes and enhanced resistance to depolarization

Mitochondrial dysfunction is a hallmark in idiopathic Parkinson’s disease (IPD). Here, we established screenable phenotypes of mitochondrial morphology and function in primary fibroblasts derived from patients with IPD. Upper arm punch skin biopsy was performed in 41 patients with mid-stage IPD and...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Antony, P. M. A., Kondratyeva, O., Mommaerts, K., Ostaszewski, M., Sokolowska, K., Baumuratov, A. S., Longhino, L., Poulain, J. F., Grossmann, D., Balling, R., Krüger, R., Diederich, N. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994699/
https://ncbi.nlm.nih.gov/pubmed/32005875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58505-6
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