Fibroblast mitochondria in idiopathic Parkinson’s disease display morphological changes and enhanced resistance to depolarization

Mitochondrial dysfunction is a hallmark in idiopathic Parkinson’s disease (IPD). Here, we established screenable phenotypes of mitochondrial morphology and function in primary fibroblasts derived from patients with IPD. Upper arm punch skin biopsy was performed in 41 patients with mid-stage IPD and...

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Vydáno v:Sci Rep
Hlavní autoři: Antony, P. M. A., Kondratyeva, O., Mommaerts, K., Ostaszewski, M., Sokolowska, K., Baumuratov, A. S., Longhino, L., Poulain, J. F., Grossmann, D., Balling, R., Krüger, R., Diederich, N. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994699/
https://ncbi.nlm.nih.gov/pubmed/32005875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58505-6
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