Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G

APOBEC3G, a member of the double-domain cytidine deaminase (CD) APOBEC, binds RNA to package into virions and restrict HIV-1 through deamination-dependent or deamination-independent inhibition. Mainly due to lack of a full-length double-domain APOBEC structure, it is unknown how CD1/CD2 domains conn...

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Publicat a:Nat Commun
Autors principals: Yang, Hanjing, Ito, Fumiaki, Wolfe, Aaron D., Li, Shuxing, Mohammadzadeh, Nazanin, Love, Robin P., Yan, Maocai, Zirkle, Brett, Gaba, Amit, Chelico, Linda, Chen, Xiaojiang S.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994475/
https://ncbi.nlm.nih.gov/pubmed/32005813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14377-y
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