HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE

Yeast vacuole fusion requires R-SNARE, Q-SNAREs, and HOPS. A HOPS SM-family subunit binds the R- and Qa-SNAREs. We now report that HOPS binds each of the four SNAREs. HOPS catalyzes fusion when the Q-SNAREs are not pre-assembled, ushering them into a functional complex. Co-incubation of HOPS, proteo...

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Bibliographic Details
Published in:eLife
Main Authors: Song, Hongki, Orr, Amy S, Lee, Miriam, Harner, Max E, Wickner, William T
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Biochemistry and Chemical Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994237/
https://ncbi.nlm.nih.gov/pubmed/31961324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53559
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