SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation

The corneocyte lipid envelope, composed of covalently bound ceramides and fatty acids, is important to the integrity of the permeability barrier in the stratum corneum, and its absence is a prime structural defect in various skin diseases associated with defective skin barrier function. SDR9C7 encod...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Takeichi, Takuya, Hirabayashi, Tetsuya, Miyasaka, Yuki, Kawamoto, Akane, Okuno, Yusuke, Taguchi, Shijima, Tanahashi, Kana, Murase, Chiaki, Takama, Hiroyuki, Tanaka, Kosei, Boeglin, William E., Calcutt, M. Wade, Watanabe, Daisuke, Kono, Michihiro, Muro, Yoshinao, Ishikawa, Junko, Ohno, Tamio, Brash, Alan R., Akiyama, Masashi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994155/
https://ncbi.nlm.nih.gov/pubmed/31671075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130675
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