SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation

The corneocyte lipid envelope, composed of covalently bound ceramides and fatty acids, is important to the integrity of the permeability barrier in the stratum corneum, and its absence is a prime structural defect in various skin diseases associated with defective skin barrier function. SDR9C7 encod...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Takeichi, Takuya, Hirabayashi, Tetsuya, Miyasaka, Yuki, Kawamoto, Akane, Okuno, Yusuke, Taguchi, Shijima, Tanahashi, Kana, Murase, Chiaki, Takama, Hiroyuki, Tanaka, Kosei, Boeglin, William E., Calcutt, M. Wade, Watanabe, Daisuke, Kono, Michihiro, Muro, Yoshinao, Ishikawa, Junko, Ohno, Tamio, Brash, Alan R., Akiyama, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994155/
https://ncbi.nlm.nih.gov/pubmed/31671075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130675
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