SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation

The corneocyte lipid envelope, composed of covalently bound ceramides and fatty acids, is important to the integrity of the permeability barrier in the stratum corneum, and its absence is a prime structural defect in various skin diseases associated with defective skin barrier function. SDR9C7 encod...

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Foilsithe in:J Clin Invest
Main Authors: Takeichi, Takuya, Hirabayashi, Tetsuya, Miyasaka, Yuki, Kawamoto, Akane, Okuno, Yusuke, Taguchi, Shijima, Tanahashi, Kana, Murase, Chiaki, Takama, Hiroyuki, Tanaka, Kosei, Boeglin, William E., Calcutt, M. Wade, Watanabe, Daisuke, Kono, Michihiro, Muro, Yoshinao, Ishikawa, Junko, Ohno, Tamio, Brash, Alan R., Akiyama, Masashi
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2020
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994155/
https://ncbi.nlm.nih.gov/pubmed/31671075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130675
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