SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation

The corneocyte lipid envelope, composed of covalently bound ceramides and fatty acids, is important to the integrity of the permeability barrier in the stratum corneum, and its absence is a prime structural defect in various skin diseases associated with defective skin barrier function. SDR9C7 encod...

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Publicado en:J Clin Invest
Autores principales: Takeichi, Takuya, Hirabayashi, Tetsuya, Miyasaka, Yuki, Kawamoto, Akane, Okuno, Yusuke, Taguchi, Shijima, Tanahashi, Kana, Murase, Chiaki, Takama, Hiroyuki, Tanaka, Kosei, Boeglin, William E., Calcutt, M. Wade, Watanabe, Daisuke, Kono, Michihiro, Muro, Yoshinao, Ishikawa, Junko, Ohno, Tamio, Brash, Alan R., Akiyama, Masashi
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994155/
https://ncbi.nlm.nih.gov/pubmed/31671075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130675
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