CD19-targeting CAR T cell immunotherapy outcomes correlate with genomic modification by vector integration

Chimeric antigen receptor–engineered T cells targeting CD19 (CART19) provide an effective treatment for pediatric acute lymphoblastic leukemia but are less effective for chronic lymphocytic leukemia (CLL), focusing attention on improving efficacy. CART19 harbor an engineered receptor, which is deliv...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Nobles, Christopher L., Sherrill-Mix, Scott, Everett, John K., Reddy, Shantan, Fraietta, Joseph A., Porter, David L., Frey, Noelle, Gill, Saar I., Grupp, Stephan A., Maude, Shannon L., Siegel, Donald L., Levine, Bruce L., June, Carl H., Lacey, Simon F., Melenhorst, J. Joseph, Bushman, Frederic D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994131/
https://ncbi.nlm.nih.gov/pubmed/31845905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130144
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